Jul 8, - According to The Instructional, the process is actually quite simple. If you're on a Mac, make sure your USB drive is formatted with the Mac OS Extended filesystem, making it fully compatible with OS X's encryption. Then, you can right-click the USB drive and encrypt it. Enter your password, and then you're done. But as with any protection you are layering more work on you. The easy way is what you noted but be sure to keep an unencrypted backup for Password protecting a USB thumb drive.